Pair Name	Oleanolic Acid, Gemcitabine
Disease Info	[ICD-11: 2C10.Z]	Pancreatic cancer		Investigative
Biological Phenomena	Induction-->Mitochondrial damage
Gene Regulation	Down-regulation	Expression	SPINK1	hsa6690
	Down-regulation	Expression	EGFR	hsa1956
	Down-regulation	Expression	MAPK1	hsa5594
	Down-regulation	Expression	MAP2K7	hsa5609
	Down-regulation	Expression	EZH2	hsa2146
In Vitro Model	AsPC-1	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0152
	MIA PaCa-2	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0428
Result	We found an interesting finding that the 73-03 in combination with GCB can improve GCB efficacy and decrease PCa resistance, which induced apoptosis and mitochondrial damage through epigenetic inhibition of SPINK1 transcription by miR-421 up-regulation. This was the first study that used OA derivatives on GCB-resistant PCa cells, so this combined strategy warrants further investigation.